In this talk we evaluatethe biocompatibility assessments required, as it pertains to the transition from gas to radiation sterilization methods for medical products. As industries increasingly explore alternative sterilization techniques, understanding the nuanced implications on biocompatibility becomes imperative. The presentation will address key considerations, challenges, and strategies involved in ensuring the safety and efficacy of medical devices during this transformative shift. What materials are most impacted and why and can biocompatibility get better or worse with the change. Join us as we navigate the intricate landscape of biocompatibility to facilitate a seamless and successful transition in sterilization processes.