The irradiation sterilization as a green and safety sterilization method is widely used in the treatment of food, medical products, herbals and agricultural products in the worldwide. The main technologies for irradiation sterilization are Gamma，Electron beam and X-ray. 

Based on the characteristics of the irradiation technology mentioned above and the current actual investment and operation situation in China, this paper focuses on economic analysis on investment of irradiation plant with different technologies under the same market conditions(medical product with density of 0.2g/cm³ and 25kGy) .

The linear accelerator (10Mev/20kW) has the best economic efficiency when the annual processing volume is below 40000 to 50000 cubic meters in China.When the annual processing volume is greater than 40000 to 50000 cubic meters, the economy of Rhodotron electron accelerator (10MeV/100kw) is the best.X-rays (7MeV, X-ray conversion efficiency of 12%) are already more economical than gamma rays when the annual processing volume is greater than 40000 to 50000 cubic meters，but there is still regulatory barriers to 7MeV X-rays, which urgently need to be promoted. The economy of X-ray (5MeV, X-ray conversion efficiency of 8%) still needs to be further improved, but due to the ability to configure and alternate with electron beams of 5 or 10MeV at the same time, the economy can be greatly improved, and it is also an optional combination method to replace cobalt sources especially the continue increasing of the price of Co-60.